Cognition and behavior in Turner syndrome: a brief review.
Publication/Presentation Date
5-1-2012
Abstract
There is increasing evidence that Turner syndrome is associated with a distinct pattern of cognitive and neurophysiological characteristics. Typically this has been characterized by relative strengths in verbal skills, contrasting with relative weaknesses in arithmetic, visuospatial and executive function domains. Potential differences in social cognitive processing have also been identified. More recently, applications of neuroimaging techniques have further elucidated underlying differences in brain structure, function and connectivity in individuals with Turner syndrome. Ongoing research in this area is focused on establishing a unified mechanistic model incorporating genetic influences from the X chromosome, sex hormone contributions, neuroanatomical variation and differences in cognitive processes. This review broadly covers current understanding of how X-monosomy impacts neurocognitive phenotype both from the perspective of cognitive-behavioral and neuroimaging studies. Furthermore, relevant clinical aspects of identifying potential learning difficulties and providing anticipatory guidance for affected individuals with TS, are briefly discussed.
Volume
9 Suppl 2
Issue
0 2
First Page
710
Last Page
712
ISSN
1565-4753
Published In/Presented At
Hong, D. S., & Reiss, A. L. (2012). Cognition and behavior in Turner syndrome: a brief review. Pediatric endocrinology reviews : PER, 9 Suppl 2(0 2), 710–712.
Disciplines
Medicine and Health Sciences
PubMedID
22946281
Department(s)
Department of Pediatrics, Department of Surgery
Document Type
Article