Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors.
Publication/Presentation Date
2-1-2012
Abstract
BACKGROUND: Congenital bicuspid aortic valves (BAVs) result from fusion of 2 valve cusps, resulting in left-noncoronary (L-N), right-left (R-L), and right-noncoronary (R-N) morphologic presentations. BAVs predispose to ascending thoracic aortic aneurysms (ATAAs). This study hypothesized that ATAAs with each BAV morphologic group possess unique signatures of matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of metalloproteinases (TIMPs).
METHODS: Ascending thoracic aortic aneurysm tissue from 46 patients with BAVs was examined for MMP/TIMP abundance, and global MMP activity was compared with normal aortic specimens (n=15). Proteolytic balance was calculated as the ratio of MMP abundance to a composite TIMP score. Results were stratified by valve morphologic group (L-N [n=6], R-L [n=31], and R-N [n=9]).
RESULTS: The BAV specimens (p
CONCLUSIONS: Each BAV morphologic group possesses a unique signature of MMPs and TIMPs. MMP/TIMP score ratios suggest that the R-L group may be more aggressive, justifying earlier surgical intervention.
Volume
93
Issue
2
First Page
457
Last Page
463
ISSN
1552-6259
Published In/Presented At
Ikonomidis, J. S., Ruddy, J. M., Benton, S. M., Jr, Arroyo, J., Brinsa, T. A., Stroud, R. E., Zeeshan, A., Bavaria, J. E., Gorman, J. H., 3rd, Gorman, R. C., Spinale, F. G., & Jones, J. A. (2012). Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors. The Annals of thoracic surgery, 93(2), 457–463. https://doi.org/10.1016/j.athoracsur.2011.09.057
Disciplines
Medicine and Health Sciences
PubMedID
22206960
Department(s)
Department of Surgery
Document Type
Article