Monoamine alterations during experimental hydrocephalus in neonatal rats.
Publication/Presentation Date
1-1-1988
Abstract
The present study was designed to determine the selected monoamine changes that occur during infantile hydrocephalus. Obstructive hydrocephalus was induced in newborn rats by injection of a suspension of kaolin into the 4th ventricle and cisterna magna. Eleven days later, experimental animals and their sham-operated littermate controls were killed and pieces of frontoparietal cortex, neostriatum, cerebellar vermis, and brain stem were processed for high performance liquid chromatography. Grossly, the lateral ventricles were extremely enlarged, the cerebral cortex was thinned, the neostriatum was compressed, and portions of the tectum and cerebellum were vacuolated. Decreases in norepinephrine (71%), dopamine (73%), and serotonin (50%) were observed in the cerebral cortex, neostriatum, and cerebellum, respectively. Brain stem norepinephrine and serotonin were increased 70% and 50%, respectively. These increases may indicate impairment of axonal transport or damage to projections from the locus ceruleus and raphe region. These preliminary results suggest that infantile hydrocephalus causes perturbations in the levels of different monoamines in several brain regions. Such changes may critically influence neuronal function and development, as well as the therapeutic management of hydrocephalus.
Volume
22
Issue
1 Pt 1
First Page
86
Last Page
91
ISSN
0148-396X
Published In/Presented At
Chovanes, G. I., McAllister, J. P., 2nd, Lamperti, A. A., Salotto, A. G., & Truex, R. C., Jr (1988). Monoamine alterations during experimental hydrocephalus in neonatal rats. Neurosurgery, 22(1 Pt 1), 86–91. https://doi.org/10.1227/00006123-198801010-00014
Disciplines
Medicine and Health Sciences
PubMedID
3344092
Department(s)
Department of Surgery
Document Type
Article