Clinical trials of amniotic membranes in burn wound care.
Publication/Presentation Date
12-1-1982
Abstract
Four test conditions of increasing complexity were used to evaluate the clinical efficacy of amniotic membranes as biologic dressings on donor sites and burn wounds in children. These were the clean-skin donor-site wound, the uncontaminated shallow partial-thickness burn wound, the bed of freshly excised full-thickness wounds, and the granulating surface of colonized burn wounds. The rate of epithelialization under amniotic membranes was the same as that under 5% scarlet red ointment or 0.5% silver nitrate solution dressings. Preservation of a healthy excised wound bed and maintenance of a low bacterial count in contaminated wounds paralleled the experience with human allograft dressings despite technical difficulties and the absence of vascularization of amniotic membrane and its fragile structure. Tentative conclusions are drawn as to the mechanisms by which biologic dressings exert their beneficial effects.
Volume
70
Issue
6
First Page
711
Last Page
717
ISSN
0032-1052
Published In/Presented At
Quinby, W. C., Jr, Hoover, H. C., Scheflan, M., Walters, P. T., Slavin, S. A., & Bondoc, C. C. (1982). Clinical trials of amniotic membranes in burn wound care. Plastic and reconstructive surgery, 70(6), 711–717. https://doi.org/10.1097/00006534-198212000-00009
Disciplines
Medicine and Health Sciences
PubMedID
6755515
Department(s)
Department of Surgery
Document Type
Article