Updates on efficacy and safety outcomes of new and emerging disease modifying therapies and stem cell therapy for Multiple Sclerosis: A review.
Publication/Presentation Date
12-1-2022
Abstract
Multiple Sclerosis (MS) is a chronic neurodegenerative autoimmune disorder of the central nervous system (CNS) and the most common cause of serious physical disability in working-age adults. Drug development and research in this field have rapidly evolved over the past two decades, leading to the broad array of treatment options available today. These disease-modifying therapies (DMTs) work through distinct mechanisms of action and exhibit varying safety and efficacy profiles to help manage symptoms and reduce exacerbations in MS patients. Our extensive understanding of this condition has also led to novel approaches, such as the discovery of specific biomarkers that allow us to monitor the therapeutic response towards DMTs. The development of new DMTs continues to progress quickly today, and it can be difficult for clinicians to remain up to date on the most recent advancements and new treatment options for their patients. In this comprehensive review, we provide an outline of current MS medications in the pipeline including emerging DMTs and stem cell therapy, as well as the unique characteristics of these medications, including their indications, pharmacokinetic effects, and the relevant advancements.
Volume
68
First Page
104125
Last Page
104125
ISSN
2211-0356
Published In/Presented At
Peterson, S., Jalil, A., Beard, K., Kakara, M., & Sriwastava, S. (2022). Updates on efficacy and safety outcomes of new and emerging disease modifying therapies and stem cell therapy for Multiple Sclerosis: A review. Multiple sclerosis and related disorders, 68, 104125. https://doi.org/10.1016/j.msard.2022.104125
Disciplines
Medicine and Health Sciences
PubMedID
36057173
Department(s)
Department of Surgery, Department of Surgery Residents, Fellows and Residents
Document Type
Article