Diffuse leptomeningeal glioneuronal tumour: where to biopsy? Case report and literature review.
Publication/Presentation Date
7-1-2021
Abstract
PURPOSE: Diffuse leptomeningeal glioneuronal tumour (DLGT) is an infrequent entity. Diagnosis is made with biopsy but with so few cases described management, prognosis remains undefined. There are not currently any articles regarding most effective place to biopsy.
METHODS: Current literature review and introduction of the case of a 3-year-old male presenting at the emergency room with irritability, vomiting and nuchal rigidity. A head CT was made showing tetraventricular enlargement and a posterior fossa cyst.
RESULTS: Patient underwent urgent ventriculoperitoneal shunting surgery with complete symptomp resolution. Brain MRI showed diffuse leptomeningeal enhancing, predominantly in basal cisterns, and multiple cystic-solid lesions along the neural axis. After ruling other conditions, a biopsy among intraoperative samples, was obtained of a PET positive gadolinium spinal enhancing lesion at D8 level, with the final diagnosis of DLGT.
CONCLUSION: DLGT can present as acute hydrocephalus. Biopsy stablishes the diagnosis but the place to take the sample can be difficult to select. Our experience suggests that PET-CT and intraoperative biopsy analysis can improve the effectivity of a representative sample.
Volume
37
Issue
7
First Page
2405
Last Page
2408
ISSN
1433-0350
Published In/Presented At
Sáez-Alegre, M., Saceda Gutiérrez, J. M., Utrilla Contreras, C., Aracil Santos, F. J., García-Feijoo, P., & Carceller Benito, F. (2021). Diffuse leptomeningeal glioneuronal tumour: where to biopsy? Case report and literature review. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 37(7), 2405–2408. https://doi.org/10.1007/s00381-020-04955-2
Disciplines
Medicine and Health Sciences
PubMedID
33128604
Department(s)
Department of Surgery, Department of Surgery Residents, Fellows and Residents
Document Type
Article