Osteomyelitis associated with peripheral vascular disease secondary to diabetes mellitus.
Publication/Presentation Date
1-1-1976
Abstract
Diabetes mellitus and arteriosclerotic vascular disease have been found to be the predisposing factors of osteomyelitis associated with peripheral vascular disease (10). A diabetic person is more susceptible to osteomyelitis because of the microangiopathy, peripheral neuropathy and decreased resistance to infection. In diabetes mellitus there can be microangiopathy which results from the proliferation of the endothelium of the intima and thickening of the basement membrane. This further contributes to a sluggish blood flow. In the patient with arteriosclerotic vascular disease, the lumens of the arterioles and arterioles are compromised by the atheromatous plaques. The anatomic structure of the blood supply to bone along with the pathologic membrane thickening, allows for slowing of blood. This slowing of blood flow causes micro-thrombi and enhances bacterial growth. In diabetes mellitus it has been shown that there is a decreased immunologic response which, along with the above, contributes to the sheltering and proliferation of bacteria in the small bones of the foot.
Volume
15
Issue
4
First Page
159
Last Page
165
ISSN
0449-2544
Published In/Presented At
DeFeo, W. T., & Jay, R. M. (1976). Osteomyelitis associated with peripheral vascular disease secondary to diabetes mellitus. The Journal of foot surgery, 15(4), 159–165.
Disciplines
Medicine and Health Sciences
PubMedID
1030728
Department(s)
Department of Surgery
Document Type
Article