Studies on the rejection of the transplanted homologous dog liver.
Publication/Presentation Date
2-1-1961
Abstract
Dogs in which livers have been replaced with hepatic homografts usually die in 5 to 10 days. Liver metabolism is not detectably abnormal at first, but gradual deterioration of function commences on the fourth or fifth day. There was histologic evidence of rejection in all dogs dying after 4 days. This ranged from minimal mononuclear infiltration to almost complete destruction of parenchyma. In the longest survivor, 20 1/2 days, histologic changes were less profound than in many animals dying earlier. Widespread histologic changes were found in host reticuloendothelial system, involving the bone marrow, kidneys, lungs, lymph nodes, and other tissues. These consisted of fixed tissue proliferation and infiltration of mononuclear cells, principally plasma cells. These changes were thought to be due to a general host reticuloendothelial response to the antigenic stimulus of the homograft.
Volume
112
First Page
135
Last Page
144
ISSN
0039-6087
Published In/Presented At
STARZL, T. E., KAUPP, H. A., Jr, BROCK, D. R., & LINMAN, J. W. (1961). Studies on the rejection of the transplanted homologous dog liver. Surgery, gynecology & obstetrics, 112, 135–144.
Disciplines
Medicine and Health Sciences
PubMedID
18979656
Department(s)
Department of Surgery
Document Type
Article