Branched chains support postoperative protein synthesis.
Publication/Presentation Date
8-1-1982
Abstract
A blinded, prospective trial of the effects of branched-chain amino acid (BcAA)-enriched total parenteral nutrition (TPN) versus standard TPN was undertaken in nonseptic noncirrhotic abdominal surgery patients and patients with multiple traumatic injuries. The study reflected data from the immediate 7-day postoperative period. With isocaloric and isonitrogenous input, the BcAA-TPN patients achieved positive nitrogen balance on day 3. Although the urinary nitrogen output was decreased by day 3 in BcAA-TPN, the plasma BcAA levels did not increase until day 6. With no change in 3-methylhistidine urinary excretion, the early nitrogen retention with BcAA-TPN probably reflects a stimulation of protein synthesis. The ability to favorably modulate the metabolic stress response with alternate fuels has become a clinical reality.
Volume
92
Issue
2
First Page
192
Last Page
199
ISSN
0039-6060
Published In/Presented At
Cerra, F. B., Upson, D., Angelico, R., Wiles, C., 3rd, Lyons, J., Faulkenbach, L., & Paysinger, J. (1982). Branched chains support postoperative protein synthesis. Surgery, 92(2), 192–199.
Disciplines
Medicine and Health Sciences
PubMedID
6808682
Department(s)
Department of Surgery
Document Type
Article