Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium.
Publication/Presentation Date
1-20-2023
Abstract
We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy improves myocardial function, perfusion, and angiogenesis in a swine model of chronic myocardial ischemia. Hypoxia-modified EVs have increased abundance of anti-oxidant, pro-angiogenic, and pro-survival proteins. The purpose of this study is to investigate the differential effects of normoxia serum-starved EVs and hypoxia-modified EVs on myocardial function, perfusion, and microvascular density in chronically ischemic myocardium. Yorkshire swine underwent placement of an ameroid constrictor to the left circumflex artery to induce chronic myocardial ischemia. Two weeks later, the pigs underwent intramyocardial injection of either normoxia serum-starved EVs (NOR,
Volume
24
Issue
3
ISSN
1422-0067
Published In/Presented At
Sabe, S. A., Xu, C. M., Potz, B. A., Malhotra, A., Sabra, M., Harris, D. D., Broadwin, M., Abid, M. R., & Sellke, F. W. (2023). Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium. International journal of molecular sciences, 24(3), 2076. https://doi.org/10.3390/ijms24032076
Disciplines
Medicine and Health Sciences
PubMedID
36768399
Department(s)
Department of Surgery, Fellows and Residents
Document Type
Article