Secondary organ dysfunction. From clinical perspectives to molecular mediators.
Publication/Presentation Date
4-1-1993
Abstract
The systemic inflammatory response and progression to secondary organ dysfunction are manifestations of the host's responses to injury. This article outlines the clinical manifestations of this injury-response cascade. The potential roles of cytokines, eicosanoids, platelet-activating factor, nitric oxide, oxygen-free radicals, and the leukocyte-endothelial interaction are explored in some detail. A goal-directed therapy of source control, resuscitation, and metabolic support is reviewed, and new therapies with monoclonal antibodies and immunomodulated nutrition are described. These new therapies hold great potential for finally improving the outcome of this fatal syndrome.
Volume
9
Issue
2
First Page
261
Last Page
298
ISSN
0749-0704
Published In/Presented At
Cipolle, M. D., Pasquale, M. D., & Cerra, F. B. (1993). Secondary organ dysfunction. From clinical perspectives to molecular mediators. Critical care clinics, 9(2), 261–298.
Disciplines
Medicine and Health Sciences
PubMedID
8490763
Department(s)
Department of Surgery
Document Type
Article