Meta-Analysis on the Effect of Pasireotide for Prevention of Postoperative Pancreatic Fistula.

Publication/Presentation Date

12-1-2020

Abstract

BACKGROUND: A randomized controlled trial of routine administration of pasireotide demonstrated decreased incidence of clinically significant postoperative pancreatic fistula (POPF). Recent studies have not replicated these results. A meta-analysis was performed to evaluate its efficacy in this setting.

METHODS: Prospective trials utilizing pasireotide prophylactically after pancreatectomy were reviewed. The primary outcome was clinically significant POPF. Secondary outcomes included length of stay (LOS), readmission rates, and mortality. Study heterogeneity was assessed.

RESULTS: Five studies totaling 1571 patients were identified. There was no difference in age, sex, or cancer rates. Pasireotide patients had smaller pancreatic ducts (

CONCLUSIONS: Routine administration of pasireotide did not decrease POPF rates for all pancreatectomies, but was associated with lower rates for PD, and decreased readmission rates. Further prospective, randomized studies are warranted.

Volume

86

Issue

12

First Page

1728

Last Page

1735

ISSN

1555-9823

Disciplines

Medicine and Health Sciences

PubMedID

32870029

Department(s)

Department of Surgery

Document Type

Article

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