Impaired cell-mediated immunity in patients with cancer.
Publication/Presentation Date
1-1-1975
Abstract
The ability of peripheral blood lymphocytes to respond in vitro to phytohemagglutinin (PHA) and to allogeneic cells in mixed leukocyte reaction (MLC) was studied in 85 patients with cancer and in 50 healthy controls. The effect produced by sera from cancer patients on in vitro lymphocyte blastogenesis was tested on autologous cells and on homologous cells from a constant panel of 10 normal volunteers. Patients with cancer showed a distinct deficiency of cellular immune responsiveness reflected in a stage-related impairment of PHA and MLC reactivity. This deficiency seems at least partially attributable to the presence of lymphocyte depressive factors in cancer sera, since such sera reduced the reactivity of both autologous and normal homologous lymphocytes to a level that was significantly lower than that found in the presence of pooled normal serum. The inhibitory activity of cancer sera was directly related to the extent of the neoplasia.
Volume
7
Issue
6
First Page
525
Last Page
529
ISSN
0022-4790
Published In/Presented At
Buda, J. A., Suciu-Foca, N., Blomain, E., McManus, S., & Reemtsma, K. (1975). Impaired cell-mediated immunity in patients with cancer. Journal of surgical oncology, 7(6), 525–529. https://doi.org/10.1002/jso.2930070613
Disciplines
Medicine and Health Sciences
PubMedID
127091
Department(s)
Department of Surgery
Document Type
Article