Severe and refractory peptic ulcer disease: the diagnostic dilemma: case report and comprehensive review.
Publication/Presentation Date
11-1-2005
Abstract
The recognition of Helicobacter pylori infection as a cause of peptic ulcer disease, medical regimens to eradicate the organism, and the widespread use of proton pump inhibition to suppress gastric acid secretion have revolutionized the management of peptic ulcer disease. As a result, successful medical management of peptic ulcer disease has largely supplanted the need for gastric surgery by general surgeons. Surgery is reserved for complications of the disease, refractory disease, or rare causes of ulcer disease such as gastrinoma and Zollinger-Ellison syndrome. In this report, we describe a case of intractable peptic ulcer disease that progressed to gastric outlet obstruction despite maximal medical therapy. We review the diagnostic studies utilized to evaluate the potential etiologies of peptic ulcer disease and the difficulty in diagnosing gastrinoma and Zollinger-Ellison in the setting of potent medical acid suppression therapy.
Volume
50
Issue
11
First Page
1999
Last Page
2008
ISSN
0163-2116
Published In/Presented At
Guzzo, J. L., Duncan, M., Bass, B. L., Bochicchio, G. V., & Napolitano, L. M. (2005). Severe and refractory peptic ulcer disease: the diagnostic dilemma: case report and comprehensive review. Digestive diseases and sciences, 50(11), 1999–2008. https://doi.org/10.1007/s10620-005-2999-5
Disciplines
Medicine and Health Sciences
PubMedID
16240207
Department(s)
Department of Surgery
Document Type
Article