Detection of P-glycoprotein in squamous cell carcinomas of the head and neck.
Publication/Presentation Date
4-1-1993
Abstract
One established mechanism of multidrug resistance is elevated expression of P-glycoprotein. The expression of P-glycoprotein by immunohistochemistry was examined in squamous cell carcinomas of the head and neck using a newly developed monoclonal antibody, UIC2, which is specific to the human MDR1 gene product and recognizes an external epitope of the protein. P-glycoprotein was detected in 60% of the samples. MDR1 expression was compared with clinical response to chemotherapy in eight patients who received MDR1-dependent drugs and response was accurately predicted in seven (89%) of eight patients. Positive P-glycoprotein staining correlated with the degree of tumor differentiation, but not with other clinical factors. Therefore, analyzing the expression of P-glycoprotein may play a role when planning chemotherapeutic regimens for patients with head and neck cancer and may be an additional prognostic and diagnostic tool in these patients.
Volume
119
Issue
4
First Page
411
Last Page
414
ISSN
0886-4470
Published In/Presented At
Kelley, D. J., Pavelic, Z. P., Gapany, M., Stambrook, P., Pavelic, L., Gapany, S., & Gluckman, J. L. (1993). Detection of P-glycoprotein in squamous cell carcinomas of the head and neck. Archives of otolaryngology--head & neck surgery, 119(4), 411–414. https://doi.org/10.1001/archotol.1993.01880160057009
Disciplines
Medicine and Health Sciences
PubMedID
8096141
Department(s)
Department of Surgery
Document Type
Article