Immunohistochemical detection of c-myc protein in head and neck tumors.

Publication/Presentation Date

3-1-1994

Abstract

OBJECTIVES: To evaluate the correlation between the levels of immunohistochemically detectable c-myc protein in squamous cell carcinoma of the head and neck and clinicopathologic prognostic variables utilized in clinical practice.

DESIGN: Cohort study.

SETTING: University and Veterans Administration medical centers, Cincinnati, Ohio.

PATIENTS OR OTHER PARTICIPANTS: Consecutive samples.

INTERVENTION: Surgery for squamous cell carcinoma of the head and neck.

MAIN OUTCOME MEASURE: Correlation between c-myc expression and tumor size, nodal involvement, clinical disease stage, and degree of differentiation. Hypothesis formulated after data collection.

RESULTS: Significant negative correlation between the c-myc levels and the number of metastatic nodes (P = .0001) and clinical stage of disease (P = .05). No correlation with tumor size or degree of differentiation.

CONCLUSIONS: Reduction or loss of c-myc oncoprotein might be associated with metastatic lymph node involvement and advanced stages of squamous cell carcinoma of the head and neck. Further studies are needed to substantiate preliminary findings.

Volume

120

Issue

3

First Page

255

Last Page

259

ISSN

0886-4470

PubMedID

8123232

Department(s)

Department of Surgery

Document Type

Article

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