Relationship between total mechanical energy and oxygen consumption in the stunned myocardium.
Publication/Presentation Date
4-1-1990
Abstract
We studied the relationship between left ventricular oxygen consumption (LVVO2) and total ventricular mechanical energy production as determined by calculation of the systolic pressure-volume area (P-VA) before and after 25 minutes of warm ischemia in 7 sheep. We compared the relationship between LVVO2 and P-VA with the relationships between LVVO2 and stroke work and between LVVO2 and the systolic stress integral. Using the methods presented, P-VA can be measured in vivo (n = 123) in both preischemic and postischemic hearts. Ischemia increases the slopes of the relationship between LVVO2 and P-VA and between stroke work and the systolic stress integral, and reduces the oxygen utilization efficiency of stroke work to less than 2%. Coefficients of determination for the relationship between LVVO2 and P-VA are, in general, higher than those between LVVO2 and either stroke work or the systolic stress integral. We conclude that systolic P-VA can be measured in vivo using recently developed methods and that it is applicable to postischemic "stunned" hearts. Because P-VA and LVVO2 can be converted into identical energy units, calculation of P-VA permits calculation of myocardial oxygen utilization efficiency.
Volume
49
Issue
4
First Page
543
Last Page
548
ISSN
0003-4975
Published In/Presented At
Furukawa, S., Bavaria, J. E., Kreiner, G., & Edmunds, L. H., Jr (1990). Relationship between total mechanical energy and oxygen consumption in the stunned myocardium. The Annals of thoracic surgery, 49(4), 543–549. https://doi.org/10.1016/0003-4975(90)90299-l
Disciplines
Medicine and Health Sciences
PubMedID
2322048
Department(s)
Department of Surgery
Document Type
Article