Myocardial oxygen utilization after reversible global ischemia.
Publication/Presentation Date
8-1-1990
Abstract
We tested in 20 sheep the hypothesis that oxygen consumption increases after reversible, global myocardial ischemia. Left ventricular oxygen consumption before and after 25 minutes of warm (37 degrees C) global ischemia was linearly related to a function (integral) of left ventricular circumferential systolic wall stress, altered by changing afterload. The relation is expressed in the two regression equations: LVO2 (preischemic) = 1.06.SSI + 16.8 (n = 129; r = 0.79); LVO2 (postischemic) = 4.35.SSI + 5.6 (n = 89; r = 0.65). The fourfold increase in slope (4.35 versus 1.06) indicates (p = 0.0001) a massive increase of oxygen consumption in postischemic, globally "stunned" myocardium. The inferences are that globally stunned myocardium causes severe impairment of oxygen utilization efficiency, and increased vulnerability to further ischemia if coronary vessels are diseased.
Volume
100
Issue
2
First Page
210
Last Page
220
ISSN
0022-5223
Published In/Presented At
Bavaria, J. E., Furukawa, S., Kreiner, G., Ratcliffe, M. B., Streicher, J., Bogen, D. K., & Edmunds, L. H., Jr (1990). Myocardial oxygen utilization after reversible global ischemia. The Journal of thoracic and cardiovascular surgery, 100(2), 210–220.
Disciplines
Medicine and Health Sciences
PubMedID
2385119
Department(s)
Department of Surgery
Document Type
Article