Primary graft failure following lung transplantation.
Publication/Presentation Date
7-1-1998
Abstract
STUDY OBJECTIVES: To determine the incidence of primary graft failure (PGF) following lung transplantation, assess possible risk factors, and characterize its effect on outcomes.
METHODS: Retrospective review of 100 consecutive patients undergoing lung transplantation at the University of Pennsylvania Medical Center. Fifteen patients meeting diagnostic criteria for PGF (PGF+ group) were compared with 85 patients without this complication (PGF- group).
RESULTS: The incidence of PGF was 15%. There was no significant difference in age, sex, underlying pulmonary disease, preoperative pulmonary artery systolic pressure, type of transplant, allograft ischemic times, use of cardiopulmonary bypass, or use of postoperative prostaglandin E1 infusion between the PGF+ and PGF- groups. Induction therapy with antilymphocyte globulin was used less frequently in the PGF+ group (p
CONCLUSIONS: PGF is a devastating postoperative complication, occurring in 15% of patients in the current series, and it is associated with a high mortality rate, lengthy hospitalization, and protracted and often compromised recovery among survivors.
Volume
114
Issue
1
First Page
51
Last Page
60
ISSN
0012-3692
Published In/Presented At
Christie, J. D., Bavaria, J. E., Palevsky, H. I., Litzky, L., Blumenthal, N. P., Kaiser, L. R., & Kotloff, R. M. (1998). Primary graft failure following lung transplantation. Chest, 114(1), 51–60. https://doi.org/10.1378/chest.114.1.51
Disciplines
Medicine and Health Sciences
PubMedID
9674447
Department(s)
Department of Surgery
Document Type
Article