Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome.
Publication/Presentation Date
7-4-2006
Abstract
BACKGROUND: Marfan syndrome (MFS) is known to cause ascending thoracic aortic aneurysms (ATAAs). Transforming growth factor beta (TGF-beta) has recently been implicated in this process. Imbalances between the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) have also been shown to contribute to aneurysm formation. Whether and to what degree MMP, TIMP, and TGF-beta signaling profiles are altered in ATAAs in MFS compared with non-MFS patients remains unknown.
METHODS AND RESULTS: ATAA samples taken during aortic replacement from age-matched MFS (n=9) and non-MFS (n=18) patients were assessed for representative subtypes of all MMP classes, all 4 known TIMPs, and type 2 TGF-beta receptors (TGFBR2). Results were expressed as a percentage (mean+/-SEM) of reference control samples (100%; n=18) obtained from patients without ATAA. In MFS, decreased MMP-2 (76+/-7; P
CONCLUSIONS: A unique MMP and TIMP portfolio was observed in ATAAs from MFS compared with non-MFS patients. In addition, MFS samples showed evidence of increased TGF-beta signaling. These differences suggest disparate mechanisms of extracellular matrix remodeling between these 2 groups of patients.
Volume
114
Issue
1 Suppl
First Page
365
Last Page
370
ISSN
1524-4539
Published In/Presented At
Ikonomidis, J. S., Jones, J. A., Barbour, J. R., Stroud, R. E., Clark, L. L., Kaplan, B. S., Zeeshan, A., Bavaria, J. E., Gorman, J. H., 3rd, Spinale, F. G., & Gorman, R. C. (2006). Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Circulation, 114(1 Suppl), I365–I370. https://doi.org/10.1161/CIRCULATIONAHA.105.000810
Disciplines
Medicine and Health Sciences
PubMedID
16820601
Department(s)
Department of Surgery
Document Type
Article