Severity and Duration of Metabolic Acidosis After Deep Hypothermic Circulatory Arrest for Thoracic Aortic Surgery.

Publication/Presentation Date

12-1-2015

Abstract

OBJECTIVE: To determine the severity, duration, and contributing factors for metabolic acidosis after deep hypothermic circulatory arrest (DHCA).

DESIGN: Retrospective observational study.

SETTING: University hospital.

PATIENTS: Eighty-seven consecutive patients undergoing elective thoracic aortic surgery with DHCA.

INTERVENTIONS: Regression analysis was used to test for relationships between the severity of metabolic acidosis and clinical and laboratory variables.

MEASUREMENTS AND MAIN RESULTS: Minimum pH averaged 7.27±0.06, with 76 (87%) having a pH

LIMITATIONS: This retrospective analysis involved short-term clinical outcomes related to pH severity and duration, which indirectly may have included the impact of sodium bicarbonate administration.

CONCLUSIONS: Metabolic acidosis was common and severe after DHCA and was attributed to both lactic and hyperchloremic acidosis. DHCA duration and temperature had little impact on the severity of metabolic acidosis. The severity of metabolic acidosis was best predicted by the BMI and had minimal effects on short-term outcomes. Preventing hyperchloremic acidosis has the potential to decrease the severity of metabolic acidosis after DHCA.

Volume

29

Issue

6

First Page

1432

Last Page

1440

ISSN

1532-8422

Disciplines

Medicine and Health Sciences

PubMedID

26706792

Department(s)

Department of Surgery

Document Type

Article

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