Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction.
Publication/Presentation Date
5-8-2017
Abstract
BACKGROUND: Bioprosthetic heart valves (BHVs), fabricated from glutaraldehyde-pretreated bovine pericardium or porcine aortic valves, are widely used for the surgical or interventional treatment of heart valve disease. Reoperation becomes increasingly necessary over time because of BHV dysfunction.
METHODS AND RESULTS: Forty-seven explanted BHV aortic valve replacements were retrieved at reoperation for clinically severe BHV dysfunction over the period 2010-2016. Clinical explant analyses of BHV leaflets for calcium (atomic absorption spectroscopy) and oxidized amino acids, per mass spectroscopy, were primary end points. Comorbidities for earlier BHV explant included diabetes mellitus and coronary artery bypass grafting. Mean calcium levels in BHV leaflets were significantly increased compared with unimplanted BHV (
CONCLUSIONS: Both increased BHV leaflet calcium levels and elevated oxidized amino acids were associated with bioprosthesis dysfunction necessitating reoperation; however, BHV calcium levels were not a determinant of implant duration, indicating a potentially important role for oxidized amino acid formation in BHV dysfunction.
Volume
6
Issue
5
ISSN
2047-9980
Published In/Presented At
Lee, S., Levy, R. J., Christian, A. J., Hazen, S. L., Frick, N. E., Lai, E. K., Grau, J. B., Bavaria, J. E., & Ferrari, G. (2017). Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction. Journal of the American Heart Association, 6(5), e005648. https://doi.org/10.1161/JAHA.117.005648
Disciplines
Medicine and Health Sciences
PubMedID
28483776
Department(s)
Department of Surgery
Document Type
Article