Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection.
Publication/Presentation Date
3-1-2022
Abstract
OBJECTIVE: The durability of root repair for acute type A aortic dissection is not well studied in the context of aortic insufficiency and stability of the sinuses of Valsalva. We compared clinical and functional outcomes in patients undergoing root repair and replacement for acute type A aortic dissection.
METHODS: Of 716 patients undergoing surgery for acute type A aortic dissection, 585 (81.7%) underwent root repair and 131 (18.3%) underwent root replacement. Survival, cumulative incidence of reoperation, aortic insufficiency, and sinuses of Valsalva dilation were compared between the 2 groups.
RESULTS: Survival at 1, 5, and 10 years was 84.1% versus 77.3%, 70.8% versus 69.2%, 57.6% versus 58.0% in the root repair and replacement groups, respectively (P = .69). Cumulative incidence of reoperation at 1, 5, and 10 years was 0.0% versus 0.8%, 1.4% versus 3.8%, and 3.4% versus 8.6% in the root repair and root replacement groups, respectively (P = .011). Multivariable Cox regression identified sinuses of Valsalva diameter 45 mm or more as a risk factor for proximal aortic reoperation (hazard ratio, 9.06; 95% confidence interval, 1.26-65.24). In a repeated-measures, linear, mixed-effects model, root replacement was associated with smaller follow-up of sinuses of Valsalva dimensions (β = -0.66, P < .001). In an ordinal longitudinal mixed model, root replacement was associated with lower severity of postoperative aortic insufficiency (β = -3.10, P < .001).
CONCLUSIONS: Survival is similar, but the incidence of aortic insufficiency and root dilation may be greater after root repair compared with root replacement for acute type A aortic dissection.
Volume
163
Issue
3
First Page
900
Last Page
910
ISSN
1097-685X
Published In/Presented At
Bojko, M. M., Assi, R., Bavaria, J. E., Suhail, M., Habertheuer, A., Hu, R. W., Harmon, J., Milewski, R. K., Desai, N. D., Szeto, W. Y., & Vallabhajosyula, P. (2022). Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection. The Journal of thoracic and cardiovascular surgery, 163(3), 900–910.e2. https://doi.org/10.1016/j.jtcvs.2020.04.064
Disciplines
Medicine and Health Sciences
PubMedID
32620395
Department(s)
Department of Surgery
Document Type
Article