Autologous Skin Cell Suspension Application for Toxic Epidermal Necrolysis: A Case Report.
Publication/Presentation Date
3-23-2022
Abstract
Toxic epidermal necrolysis (TEN) is a drug-mediated disease process that mimics a partial-thickness thermal injury. It has long been treated with frequent wound dressing changes and supportive care. There has been minimal efficacious systemic therapy. The pathophysiology is poorly understood but causes necrosis of keratinocytes at the dermal-epidermal junction leading to sloughing of the epidermis. The disease is rare with high mortality rates associated with long hospital stays. This case report describes the application of autologous skin cell suspension to a patient with TEN after antihypertensive and hyperglycemic therapy. This was associated with minimal wound care and efficacious arrest of patient disease process and timely closure of wound.
Volume
43
Issue
2
First Page
508
Last Page
513
ISSN
1559-0488
Published In/Presented At
Pang, A., Pham, T., Felan, S., Raghuram, A., Brown, E., Bharadia, D., & Griswold, J. (2022). Autologous Skin Cell Suspension Application for Toxic Epidermal Necrolysis: A Case Report. Journal of burn care & research : official publication of the American Burn Association, 43(2), 508–513. https://doi.org/10.1093/jbcr/irab243
Disciplines
Medicine and Health Sciences
PubMedID
34902031
Department(s)
Department of Surgery
Document Type
Article