Cancer of the gallbladder associated with pancreaticobiliary maljunction without bile duct dilatation in a european patient.
Publication/Presentation Date
1-1-2000
Abstract
A rare case of pancreaticobiliary maljunction (PBM) without dilatation of the biliary tract (DBT) associated with gallbladder carcinoma is described herein. A 62-year-old European woman with a long history of right upper abdominal pain was diagnosed as having PBM without DBT by endoscopic retrograde cholangiopancreatography and other examinations. Excision of the gallbladder and biliary duct with a Roux-en-Y hepaticojejunostomy was performed, and subsequent pathological examination of the surgical specimen showed a well differentiated adenocarcinoma of the gallbladder. She had no clinical symptoms for 58 months postoperatively. PBM allows reflux of pancreatic juice into the biliary tract. Recent findings support the idea that epithelial hyperplasia plays an important role in gallbladder carcinogenesis with PBM, and also support the concept that gene mutations are involved in the carcinogenesis of biliary epithelium in patients with PBM. For these reasons, we advocate that resection of the extrahepatic biliary tract in PBM patients without bile duct dilatation, rather than cholecystectomy alone, is the treatment of choice for preventing bile duct carcinoma.
Volume
7
Issue
3
First Page
336
Last Page
338
ISSN
0944-1166
Published In/Presented At
Tuech, J. J., Pessaux, P., Aube, C., Regenet, N., Cervi, C., Bergamaschi, R., & Arnaud, J. P. (2000). Cancer of the gallbladder associated with pancreaticobiliary maljunction without bile duct dilatation in a european patient. Journal of hepato-biliary-pancreatic surgery, 7(3), 336–338. https://doi.org/10.1007/s005340070059
Disciplines
Medicine and Health Sciences
PubMedID
10982637
Department(s)
Department of Surgery
Document Type
Article