Does race affect postoperative outcomes in patients with low-risk prostate cancer who undergo radical prostatectomy?
Publication/Presentation Date
3-1-2009
Abstract
OBJECTIVES: To assess the magnitude of racial disparities in prostate cancer outcomes following radical prostatectomy for low-risk prostate cancer.
METHODS: We retrospectively reviewed our database of 2407 patients who under went radical prostatectomy and isolated 2 cohorts of patients with low-risk prostate cancer. Cohort 1 was defined using liberal criteria, and cohort 2 was isolated using more stringent criteria. We then studied pre- and postoperative parameters to discern any racial differences in these 2 groups. Statistical analyses, including log-rank, chi(2), and Fisher's exact analyses, were used to ascertain the significance of such differences.
RESULTS: Preoperatively, no significant differences were found between the white and African-American patients with regard to age at diagnosis, mean prostate-specific antigen, median follow-up, or percentage of involved cores on prostate biopsy. African-American patients in cohort 1 had a greater mean body mass index than did white patients (26.9 vs 27.8, P = .026). The analysis of postoperative data demonstrated no significant difference between white and African-American patients in the risk of biochemical failure, extraprostatic extension, seminal vesicle involvement, positive surgical margins, tumor volume, or risk of disease upgrading. African-American patients in cohort 2 demonstrated greater all-cause mortality compared with their white counterparts (9.4% vs 3.1%, P = .027).
CONCLUSIONS: In patients with low-risk prostate cancer treated with radical prostatectomy, there exist no significant differences in surrogate measures of disease control, risk of disease upgrading, estimated tumor volume, or recurrence-free survival between whites and African-Americans.
Volume
73
Issue
3
First Page
620
Last Page
623
ISSN
1527-9995
Published In/Presented At
Resnick, M. J., Canter, D. J., Guzzo, T. J., Brucker, B. M., Bergey, M., Sonnad, S. S., Wein, A. J., & Malkowicz, S. B. (2009). Does race affect postoperative outcomes in patients with low-risk prostate cancer who undergo radical prostatectomy?. Urology, 73(3), 620–623. https://doi.org/10.1016/j.urology.2008.09.035
Disciplines
Medicine and Health Sciences
PubMedID
19100607
Department(s)
Department of Surgery
Document Type
Article