Experimental liver metastasis. Implications of clonal proclivity and organ specificity.
Publication/Presentation Date
1-1-1989
Abstract
"Spontaneous" lung metastases develop in over 50% of the animals bearing subcutaneous isografts of WB-2054, a rat colon carcinoma. A metastatic variant has been developed by "Fidler" type in vivo selection, yielding 100% lung metastasis. In a five-week assay to test the organ specificity of this lung metastatic variant, however, "experimental" liver and lung metastases could be induced in 100% and 60% of animals on portal venous and intravenous injections, respectively. The results demonstrate selection of a metastatic variant from heterogeneous primary tumor, and suggest at least two interacting mechanisms: (1) mechanical (the anatomy of the blood-borne metastatic pathways) and (2) biologic (factors intrinsic to primary tumor subpopulations that can be selected for metastatic proclivity). In addition, liver metastases were successfully established from colon tumors induced by cecal wall injection of tumor cells. Such a spontaneous liver metastasis model will be useful to study the specific mechanisms involved during metastasis of colon cancer to the liver.
Volume
124
Issue
1
First Page
49
Last Page
54
ISSN
0004-0010
Published In/Presented At
Ravikumar, T. S., D'Emilia, J., Cocchiaro, C., Wolf, B., King, V., & Steele, G., Jr (1989). Experimental liver metastasis. Implications of clonal proclivity and organ specificity. Archives of surgery (Chicago, Ill. : 1960), 124(1), 49–54. https://doi.org/10.1001/archsurg.1989.01410010059013
Disciplines
Medicine and Health Sciences
PubMedID
2910247
Department(s)
Department of Surgery
Document Type
Article