The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma.
Publication/Presentation Date
3-1-1995
Abstract
BACKGROUND: Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome that affects a significant percentage of the total cancer population but is not easily recognized because of a lack of a distinctive clinical marker such as multiple polyps.
DATA SOURCES: The present review discusses the clinical characteristics, pathology, genetics, management, and surveillance of HNPCC. The diagnosis of HNPCC is dependent upon family history. It is defined by the Amsterdam criteria consisting of: (1) 3 or more relatives with histologically verified colorectal carcinoma, 1 of whom is a first-degree relative of the other 2; (2) colorectal carcinoma involving at least two generations; and (3) one or more colorectal carcinoma cases diagnosed at less than 50 years of age.
CONCLUSIONS: The diagnosis of HNPCC requires the demonstration of vertical transmission of the syndrome in the family pedigree. Attention should be focused on reports of cancer of all anatomic sites and the determination of site, histology, and age at diagnosis.
Volume
169
Issue
3
First Page
368
Last Page
372
ISSN
0002-9610
Published In/Presented At
D'Emilia, J. C., Rodriguez-Bigas, M. A., & Petrelli, N. J. (1995). The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma. American journal of surgery, 169(3), 368–372. https://doi.org/10.1016/S0002-9610(99)80178-0
Disciplines
Medicine and Health Sciences
PubMedID
7879846
Department(s)
Department of Surgery
Document Type
Article