Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.
Publication/Presentation Date
2-1-1991
Abstract
With the use of viral vectors harboring myc and src oncogenes, we have assessed the potential contribution of these different elements to colonic neoplasia using a transplantation technique resulting in the formation of a heterotopic colon in Wistar Furth rats. While myc alone induced atypia and some dysplasia, src induced focal dysplastic lesions throughout the colon mucosa with evidence of metaplasia. In contrast, lesions induced by myc and src acting cooperatively, were highly dysplastic with evidence of tumor formation after protracted periods. These results indicated the formation of histologically distinct preneoplastic lesions elicited by the action of a single oncogene in colon implants with the production of adenocarcinomas when such oncogenic elements act cooperatively. This model provides an opportunity for studies of the action of different oncogenes, acting singly or in combination, in the multi-step progression to colon tumor formation.
Volume
6
Issue
2
First Page
303
Last Page
309
ISSN
0950-9232
Published In/Presented At
D'Emilia, J. C., Mathey-Prevot, B., Jaros, K., Wolf, B., Steele, G., Jr, & Summerhayes, I. C. (1991). Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. Oncogene, 6(2), 303–309.
Disciplines
Medicine and Health Sciences
PubMedID
2000223
Department(s)
Department of Surgery
Document Type
Article