Renin, angiotensin II, and the development of effusions following bidirectional Glenn and Fontan procedures.
Publication/Presentation Date
3-1-1995
Abstract
Pleural effusions are a troublesome complication following bidirectional Glenn and Fontan procedures. It was our hypothesis that effusions may be related to alterations in hormones that regulate fluid homeostasis. We made serial determinations (by radioimmunoassay) of antidiuretic hormone, cortisol, aldosterone, angiotensin II, and renin in patients undergoing bidirectional Glenn (n = 16) and Fontan procedures (n = 24). There were six patients who developed effusions following surgery. These patients had a different endocrinological pattern characterized by persistent elevation in renin (28 +/- 9 vs 9 +/- 5 ng/mL per hour, p < 0.01) and angiotensin II (110 +/- 33 vs 33 +/- 14 ng/L, p < 0.01) on the fifth postoperative day as compared to patients who did not develop effusions. These data demonstrate that patients who develop effusions following bidirectional Glenn and Fontan procedures have activation of their renin-angiotensin system.
Volume
10
Issue
2
First Page
111
Last Page
118
ISSN
0886-0440
Published In/Presented At
Mainwaring, R. D., Lamberti, J. J., Carter, T. L., Jr, Moore, J. W., & Nelson, J. C. (1995). Renin, angiotensin II, and the development of effusions following bidirectional Glenn and Fontan procedures. Journal of cardiac surgery, 10(2), 111–118. https://doi.org/10.1111/j.1540-8191.1995.tb01228.x
Disciplines
Medicine and Health Sciences
PubMedID
7772874
Department(s)
Department of Surgery
Document Type
Article