Heterotransplantation of Nb rat prostatic adenocarcinomas into congenitally athymic nude mice.
Publication/Presentation Date
1-1-1981
Abstract
Although Nb rat prostatic adenocarcinoma rarely occurs spontaneously, the frequency of occurrences is increased by hormone induction. In this study, the Nb rat prostatic adenocarcinomas, Pr-90 and 13-Pr-12, were heterotransplanted into congenitally athymic (nude) mice for the purpose of evaluating the response of these tumors to chemotherapeutic agents. Adriamycin and methotrexate were evaluated in treating both tumors, and cyclophosphamide and BCNU + 5 FU were evaluated in 13-Pr-12. This paper reviews the treatment of autonomous tumors at varying tumor volume, as well as the use of chemotherapeutic modalities at various dosage levels. Significance was observed in animals treated with cyclophosphamide, as well as methotrexate, and at the highest dose of Adriamycin (P 7E 0.05). Complete tumor regression and marked tumor volume decrease were observed in animals treated with cyclophosphamide and methotrexate. Recent reports have led to some optimism in treating human prostatic adenocarcinomas with Adriamycin and cyclophosphamide.
Volume
47
Issue
1
First Page
55
Last Page
59
ISSN
0008-543X
Published In/Presented At
Drago, J. R., & Gershwin, M. E. (1981). Heterotransplantation of Nb rat prostatic adenocarcinomas into congenitally athymic nude mice. Cancer, 47(1), 55–59. https://doi.org/10.1002/1097-0142(19810101)47:1<55::aid-cncr2820470111>3.0.co;2-w
Disciplines
Medicine and Health Sciences
PubMedID
7193077
Department(s)
Department of Surgery
Document Type
Article