Evaluation of chemotherapeutic responsiveness in Nb rat prostate cancer model. 5-fluorouracil, methotrexate, cyclophosphamide, and adriamycin.
Publication/Presentation Date
7-1-1980
Abstract
We elevated four chemotherapeutic agents in 105 male Nb rats with transplanted Nb rat prostatic tumors. Tumor volume and the presence or absence of metastasis were determined at the completion of the experiment and served as indicators of agent effectiveness. 5-Fluorouracil and cyclophosphamide were the most effective agents (P < 0.01). Seven of ten animals treated with cyclophosphamide had complete tumor regression; only one had pulmonary visceral or mediastinal metastasis. In other chemotherapeutic and control groups, no animal had complete tumor regression and approximately 50% of the experimental animals developed metastases despite chemotherapy. Final tumor volume was significantly reduced when compared to controls in the high-dose methotrexate doxorubicin hydrochloride (Adriamycin), cyclophosphamide, and both 5-fluorouracil groups (P < 0.01).
Volume
18
Issue
1
First Page
80
Last Page
81
ISSN
0021-0005
Published In/Presented At
Drago, J. R., Goldman, L., & Gershwin, M. E. (1980). Evaluation of chemotherapeutic responsiveness in Nb rat prostate cancer model. 5-fluorouracil, methotrexate, cyclophosphamide, and adriamycin. Investigative urology, 18(1), 80–81.
Disciplines
Medicine and Health Sciences
PubMedID
7410017
Department(s)
Department of Surgery
Document Type
Article