Evaluation of nonhormonal cytotoxic chemotherapy in the Nb rat (Pr-90) prostatic carcinoma.
Publication/Presentation Date
2-15-1980
Abstract
The Nb rat prostate adenocarcinoma occurs spontaneously. The frequency of occurrence is increased by hormone induction. Tumors are classified as autonomous or estrogen or androgen dependent, based on their response to hormone manipulation. These rats provide a unique animal model for the evaluation of biological activity, hormone dependency, and the screening of therapeutic modalities. This report evaluates the use of cyclophosphamide, Adriamycin and methotrexate on the autonomous Pr-90 tumor. Methotrexate and Adriamycin were evaluated at two different concentrations, which demonstrated statistically significant results. Cyclophosphamide treatment resulted in complete tumor regression in eight of 12 tumors. Evidence of Adriamycin cardiotoxicity was found at autopsy.
Volume
45
Issue
4
First Page
757
Last Page
763
ISSN
0008-543X
Published In/Presented At
Drago, J. R., & Goldman, L. B. (1980). Evaluation of nonhormonal cytotoxic chemotherapy in the Nb rat (Pr-90) prostatic carcinoma. Cancer, 45(4), 757–763. https://doi.org/10.1002/1097-0142(19800215)45:4<757::aid-cncr2820450424>3.0.co;2-b
Disciplines
Medicine and Health Sciences
PubMedID
7357493
Department(s)
Department of Surgery
Document Type
Article