The Nb rat prostatic adenocarcinoma's dose response to methotrexate and adriamycin.
Publication/Presentation Date
11-1-1983
Abstract
The Noble rat prostatic adenocarcinoma, Nb-Pr-A.I.-II, an androgen-insensitive tumor, is the subject of this experiment. Dose responses were carried out with treatment of these tumors with three doses of adriamycin and two doses of methotrexate. Adriamycin treatment resulted in decreased tumor volume and decreased number of metastases in the higher dosage. Methotrexate also decreased metastasis and tumor volume. No animal treated with either of these agents in this protocol had the tumor undergo complete tumor regression, a criteria used in evaluation of chemotherapies with this animal model.
Volume
24
Issue
3
First Page
215
Last Page
217
ISSN
0022-4790
Published In/Presented At
Drago, J. R., & Palmer, J. (1983). The Nb rat prostatic adenocarcinoma's dose response to methotrexate and adriamycin. Journal of surgical oncology, 24(3), 215–217. https://doi.org/10.1002/jso.2930240315
Disciplines
Medicine and Health Sciences
PubMedID
6632910
Department(s)
Department of Surgery
Document Type
Article