Clinical effect of aminoglutethimide, medical adrenalectomy, in treatment of 43 patients with advanced prostatic carcinoma.
Publication/Presentation Date
4-1-1984
Abstract
The initial treatment of patients with Stage D prostatic carcinoma with orchiectomy or estrogens is successful in giving objective and subjective improvement for variable periods of time. However, after initial endocrine treatment patients generally relapse, and go on to further progression of their disease. However, a subgroup of approximately 22% of these Stage D prostatic cancer patients respond to either surgical adrenalectomy or hypophysectomy, indicating some degree of continued hormonal responsiveness. Forty-three previously castrated patients with Stage D prostatic carcinoma were treated with 1000 mg of aminoglutethimide and 40 mg of hydrocortisone daily and have been evaluated using the criteria of the National Prostatic Cancer Project. Progression of disease after initial hormonal therapy has varied from 3 to 25 months. One patient has had a complete response, and continues in remission after 290 weeks of therapy. Partial objective responses have been observed in 6 patients, and 10 patients have remained objectively stable for an average of 35 weeks in this latter group.
Volume
53
Issue
7
First Page
1447
Last Page
1450
ISSN
0008-543X
Published In/Presented At
Drago, J. R., Santen, R. J., Lipton, A., Worgul, T. J., Harvey, H. A., Boucher, A., Manni, A., & Rohner, T. J. (1984). Clinical effect of aminoglutethimide, medical adrenalectomy, in treatment of 43 patients with advanced prostatic carcinoma. Cancer, 53(7), 1447–1450. https://doi.org/10.1002/1097-0142(19840401)53:7<1447::aid-cncr2820530703>3.0.co;2-g
Disciplines
Medicine and Health Sciences
PubMedID
6697289
Department(s)
Department of Surgery
Document Type
Article