Nb rat prostate adenocarcinoma model: metastasis.
Publication/Presentation Date
1-1-1985
Abstract
The Nb rat prostate adenocarcinomas - androgen insensitive II and III - were utilized in three experiments utilizing protamine sulfate, persantine (dipyridamole), and heparin-cortisone combination as agents evaluated for their ability to affect the incidence of systemic metastasis in this animal model. The results indicate that all agents tested were effective in reducing metastasis; protamine and persantine (10 mg/kg/day) being the most effective with 0% metastasis. In addition, animals treated with protamine had a statistically significant decrease in tumor volume. The mechanism responsible for this decrease remains unclear at present.
Volume
5
Issue
2
First Page
193
Last Page
196
ISSN
0250-7005
Published In/Presented At
Drago, J. R., Curley, R. M., & Sipio, J. C. (1985). Nb rat prostate adenocarcinoma model: metastasis. Anticancer research, 5(2), 193–196.
Disciplines
Medicine and Health Sciences
PubMedID
2581494
Department(s)
Department of Surgery
Document Type
Article