Relative value of prostate-specific antigen and prostatic acid phosphatase in diagnosis and management of adenocarcinoma of prostate. Ohio State University experience.
Publication/Presentation Date
10-1-1989
Abstract
Serum concentrations of prostate-specific antigen (PSA), prostate-specific acid phosphatase (PAP), and transrectal prostatic ultrasound were utilized in the evaluation of 193 men with various urologic disorders. Of the 193 patients, 48 had prostate cancer, and the other 145 included 5 with genitourinary neoplasms, 69 with benign prostatic hypertrophy, and 71 with other non-neoplastic genitourinary disease. PSA levels were elevated in 35 patients with prostate cancer and in 25 of the 145 without prostate cancer. PAP levels were elevated in 15 with prostate cancer and in 2 of the 145 without prostate cancer. The data indicate that PSA is a more sensitive but less specific tumor marker than PAP in the detection of prostate cancer. PSA appears to be more sensitive than PAP in monitoring the response to treatment. The use of PSA and PAP jointly to detect and to monitor prostate cancer did not appear to enhance the clinical utility over that of PSA alone.
Volume
34
Issue
4
First Page
187
Last Page
192
ISSN
0090-4295
Published In/Presented At
Drago, J. R., Badalament, R. A., Wientjes, M. G., Smith, J. J., Nesbitt, J. A., York, J. P., Ashton, J. J., & Neff, J. C. (1989). Relative value of prostate-specific antigen and prostatic acid phosphatase in diagnosis and management of adenocarcinoma of prostate. Ohio State University experience. Urology, 34(4), 187–192. https://doi.org/10.1016/0090-4295(89)90369-5
Disciplines
Medicine and Health Sciences
PubMedID
2477931
Department(s)
Department of Surgery
Document Type
Article