Immunosuppressive preconditioning or induction regimens : evidence to date.

Publication/Presentation Date

1-1-2006

Abstract

The success of solid organ transplantation has been directly related to the development of immunosuppressive drug therapies. Preconditioning or induction therapy was developed to reduce early immunological and nonimmunological renal injury, with the goal of increasing long-term graft survival. However, the routine induction of immunological tolerance to solid organ allograft is currently not achievable because of the morbidity and mortality related to the immunosuppressive regimens themselves. The different therapeutic preconditioning or induction agents and their associated effects on cellular rejection, graft survival outcomes and the need for multiagent post-transplant maintenance therapy are reviewed.

Volume

66

Issue

12

First Page

1535

Last Page

1545

ISSN

0012-6667

Disciplines

Medicine and Health Sciences

PubMedID

16956302

Department(s)

Department of Surgery

Document Type

Article

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