The impact of obesity on overall and cancer specific survival in men with prostate cancer.
Publication/Presentation Date
7-1-2009
Abstract
PURPOSE: We examined the impact of obesity on disease specific and overall survival in patients with prostate cancer.
MATERIALS AND METHODS: We identified 7,274 men from the Cancer of the Prostate Strategic Urological Research Endeavor database with clinically localized prostate cancer, known body mass index and clinicopathological disease characteristics. Patients were classified by body mass index as normal (less than 25 kg/m(2)), overweight (25 to 29.9 kg/m(2)), obese (30 to 34.9 kg/m(2)) and severely obese (35 kg/m(2) or greater). Associations between body mass index and need for secondary treatment, disease specific survival and overall survival were analyzed using univariate and multivariate models.
RESULTS: Patients were classified by body mass index category as normal (28.8%), overweight (50%), obese (16.4%) and very obese (4.8%). Mean followup was 51.3 +/- 38.5 months. During followup there were 1,044 deaths with 220 (21.1%) from prostate cancer. Stratified by body mass index category the groups differed with regard to the need for secondary treatment (p = 0.05) and overall mortality (p
CONCLUSIONS: In a prospective, community based cohort we were unable to establish a relationship between body mass index and prostate cancer disease specific survival or overall survival.
Volume
182
Issue
1
First Page
112
Last Page
117
ISSN
1527-3792
Published In/Presented At
Davies, B. J., Smaldone, M. C., Sadetsky, N., Dall'era, M., & Carroll, P. R. (2009). The impact of obesity on overall and cancer specific survival in men with prostate cancer. The Journal of urology, 182(1), 112–117. https://doi.org/10.1016/j.juro.2009.02.118
Disciplines
Medicine and Health Sciences
PubMedID
19447437
Department(s)
Department of Surgery
Document Type
Article