The fibrinolytic system in experimental prostate tumor.
Publication/Presentation Date
10-21-1986
Abstract
Hypofibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.
Volume
56
Issue
2
First Page
133
Last Page
136
ISSN
0340-6245
Published In/Presented At
Al-Mondhiry, H., Drago, J., & Bartholomew, M. J. (1986). The fibrinolytic system in experimental prostate tumor. Thrombosis and haemostasis, 56(2), 133–136.
Disciplines
Medicine and Health Sciences
PubMedID
3810552
Department(s)
Department of Surgery
Document Type
Article