Effect of isoproterenol (ISO) on rat heart, liver, kidney, and muscle tissue levels of zinc, copper, and magnesium.
Publication/Presentation Date
9-1-1986
Abstract
X-ray fluorescence and atomic absorption spectrometry were used to measure the concentrations of zinc, copper, and magnesium in the heart, liver, skeletal muscle, and kidney following isoproterenol-induced myocardial necrosis in male albino rats. Serum activities of lactic dehydrogenase (LDH), creatine phosphokinase (CPK), and glutamic oxaloacetic transaminase (SGOT) were also measured. There was depletion of myocardial zinc, copper, and magnesium on d 1, followed by an uptake of all these elements on d 2. The liver showed a significant uptake of magnesium, along with depletion of copper. There was no change in the kidney and skeletal muscle concentrations of these elements. Possible explanations for the observed changes and their therapeutic significance are presented.
Volume
10
Issue
3
First Page
189
Last Page
199
ISSN
0163-4984
Published In/Presented At
Zama, N., & Towns, R. L. (1986). Effect of isoproterenol (ISO) on rat heart, liver, kidney, and muscle tissue levels of zinc, copper, and magnesium. Biological trace element research, 10(3), 189–199. https://doi.org/10.1007/BF02795617
Disciplines
Medicine and Health Sciences
PubMedID
24254393
Department(s)
Department of Surgery
Document Type
Article