Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients.
Publication/Presentation Date
3-1-2014
Abstract
OBJECTIVE: To retrospectively assess the safety and efficacy of endovascular treatment of cerebral vasospasm with different modalities and assess predictors of outcome.
METHODS: Endovascular treatment was indicated in the event of neurological deterioration refractory to medical therapy. Data were collected for 116 patients treated at our institution.
RESULTS: Vasospasm was treated with balloon angioplasty in 52.6%, intra-arterial nicardipine infusion in 19.8%, or both in 27.6%. Angiographic vasospasm was reversed in all but 4 (96.6%) patients. The complication rate was 0.9%. Twenty patients (17.2%) had incipient pre-procedure hypodensities; 3 (15%) hypodensities were reversed and neurological improvement occurred in 60% of these patients. Retreatment was required in 22 (19%) patients. Higher Hunt and Hess grades and treatment with nicardipine alone predicted retreatment. Neurological improvement was noted in 82%. Male gender, pre-procedure hypodensities, and posterior communicating artery aneurysm location negatively predicted neurological recovery. Favorable outcomes were noted in 73%. Higher Hunt and Hess grades, pre-procedure hypodensities, posterior circulation aneurysms, and no neurological recovery predicted poor outcome.
CONCLUSION: Endovascular therapy for vasospasm has an excellent safety-efficacy profile. Balloon angioplasty and nicardipine are equally effective but effects of nicardipine are less durable. Patients with incipient pre-procedure hypodensities benefit from endovascular intervention and should probably not be excluded from treatment.
Volume
118
First Page
26
Last Page
31
ISSN
1872-6968
Published In/Presented At
Chalouhi, N., Tjoumakaris, S., Thakkar, V., Theofanis, T., Hammer, C., Hasan, D., Starke, R. M., Wu, C., Gonzalez, L. F., Rosenwasser, R., & Jabbour, P. (2014). Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients. Clinical neurology and neurosurgery, 118, 26–31. https://doi.org/10.1016/j.clineuro.2013.12.012
Disciplines
Medicine and Health Sciences
PubMedID
24529225
Department(s)
Department of Surgery
Document Type
Article
