"Vascular and neuronal effects of general anesthesia on the brain: An f" by Faezeh Vedaei, Mahdi Alizadeh et al.
 

Vascular and neuronal effects of general anesthesia on the brain: An fMRI study.

Publication/Presentation Date

1-1-2023

Abstract

BACKGROUND AND PURPOSE: A number of functional magnetic resonance imaging (fMRI) studies rely on application of anesthetic agents during scanning that can modulate and complicate interpretation of the measured hemodynamic blood oxygenation level-dependent (BOLD) response. The purpose of the present study was to investigate the effect of general anesthesia on two main components of BOLD signal including neuronal activity and vascular response.

METHODS: Breath-holding (BH) fMRI was conducted in wakefulness and under anesthesia states in 9 patients with drug-resistant epilepsy who needed to get scanned under anesthesia during laser interstitial thermal therapy. BOLD and BOLD cerebrovascular reactivity (BOLD-CVR) maps were compared using t-test between two states to assess the effect of anesthesia on neuronal activity and vascular factors (p < .05).

RESULTS: Overall, our findings revealed an increase in BOLD-CVR and decrease in BOLD response under anesthesia in several brain regions. The results proposed that the modulatory mechanism of anesthetics on neuronal and vascular components of BOLD signal may work in different ways.

CONCLUSION: This experiment for the first human study showed that anesthesia may play an important role in dissociation between neuronal and vascular responses contributed to hemodynamic BOLD signal using BH fMRI imaging that may assist the implication of general anesthesia and interpretation of outcomes in clinical setting.

Volume

33

Issue

1

First Page

109

Last Page

120

ISSN

1552-6569

Disciplines

Medicine and Health Sciences

PubMedID

36097249

Department(s)

Department of Surgery

Document Type

Article

Link to Full Text

Share

COinS