"Facility type and size-stratified analysis of management patterns and " by Jonathan J Hue, Kavin Sugumar et al.
 

Facility type and size-stratified analysis of management patterns and outcomes of patients with localized non-functional pancreatic neuroendocrine tumors.

Publication/Presentation Date

4-1-2022

Abstract

BACKGROUND: Non-functional neuroendocrine tumors of the pancreas (NF-pNETs) are uncommon. Consensus guidelines have conflicting recommendations. We performed a nationwide analysis of patterns in management and outcomes based on facility type and tumor size.

METHODS: The National Cancer Database (2004-2016) was queried for patients with localized NF-pNETs (<1 >cm, 1-2 cm, >2 cm) stratified by facility type. Management decisions, operative outcomes, and survival were compared.

RESULTS: A total of 7170 patients were included in the analysis (= 916; 1-2 cm = 2180; >2 cm = 4074). Most patients were treated at academic facilities (62.8%). Over 67% of patients with tumorsresection, independent of facility type (p = 0.443). There was no association between facility type and operative vs non-operative management of patients with NF-pNETs 1-2 cm in size. Patients treated at academic facilities were more likely to undergo resection for tumors >2 cm compared to other facility types. Resection was associated with improved survival among patients with tumors 1-2 cm (HR = 0.43,p < 0.001) and >2 cm (HR = 0.32,p < 0.001), but not

CONCLUSION: There is heterogeneity in management of NF-pNETs across facility types. Treatment at academic facilities appears to be associated with higher resection rates for tumors >2 cm. There appears to be an independent association between operative management and improved survival for tumors ≥1 cm in size.

Volume

24

Issue

4

First Page

498

Last Page

506

ISSN

1477-2574

Disciplines

Medicine and Health Sciences

PubMedID

34419354

Department(s)

Department of Surgery, Lehigh Valley Topper Cancer Institute

Document Type

Article

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