Massive Macronodular Juvenile Xanthogranuloma of the Eyelid in a Newborn.
Publication/Presentation Date
4-1-2014
Abstract
A newborn baby with a lump on his right upper eyelid that was unresponsive to warm compresses and oral antibiotics presented at 3 weeks of age with a yellow mass measuring 20 mm in diameter at the base. Preliminary diagnosis was benign choristomatous mass; and warm compresses were continued. The mass continued to enlarge and 5 weeks later was 35 mm, with a tight, atrophic overlying epidermis and greater pupillary occlusion. Concern for possible malignancy prompted surgical resection and reconstruction with a supraclavicular graft. Histopathology disclosed that the eyelid tissue was nearly completely replaced by a highly cellular histiocytic neoplasm with prominent eosinophilic, often foamy cytoplasm, and nuclear pleomorphism. Poorly formed Touton giant cells were found. The mass showed positive immunoreactivity, with histiocytic markers CD163 and factor XIII, and was negative for cytokeratin markers, smooth muscle actin, and desmin. These features were compatible with JXG.
Volume
18
Issue
2
First Page
195
Last Page
197
ISSN
1528-3933
Published In/Presented At
Shields, C. L., Thaler, A. S., Lally, S. E., Lin, C. J., Trachtman, M. S., Eagle, R. J., & Shields, J. A. (2014). Massive macronodular juvenile xanthogranuloma of the eyelid in a newborn. Journal Of AAPOS: The Official Publication Of The American Association For Pediatric Ophthalmology And Strabismus / American Association For Pediatric Ophthalmology And Strabismus, 18(2), 195-197. doi:10.1016/j.jaapos.2013.11.023
Disciplines
Other Medical Specialties | Surgery
PubMedID
24698623
Peer Reviewed for front end display
Peer-Reviewed
Department(s)
Department of Surgery
Document Type
Article