"Mortality and Survival Among Octogenarians with Localized Pancreatic H" by Jonathan J Hue, Katherine Bingmer et al.
 

Mortality and Survival Among Octogenarians with Localized Pancreatic Head Cancer: a National Cancer Database Analysis.

Publication/Presentation Date

10-1-2021

Abstract

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has historically poor outcomes. Difficult decisions must be made by patients and providers, especially in the elderly for whom treatment morbidities may not be tolerable. Herein, we report treatment-dependent outcomes of octogenarians with localized PDAC.

METHODS: The National Cancer Database identified patients ≥60 years with localized PDAC of the pancreatic head (2011-2016). Patients were grouped by age (60-79 and ≥80 years) and categorized by treatment regimen: no treatment, chemotherapy, pancreaticoduodenectomy, pancreaticoduodenectomy with perioperative chemotherapy, or pancreaticoduodenectomy with adjuvant chemotherapy. Postoperative outcomes and survival were analyzed.

RESULTS: A total of 35,409 patients were included, 8745 (24.7%) of which were ≥80 years. Over 52% of octogenarians did not receive any treatment, compared to 19.1% of younger patients (p

CONCLUSION: Increasing age is associated with worse overall survival in PDAC, but select octogenarians can achieve reasonable survival with multimodal therapy. Given the poor survival and increased perioperative mortality of octogenarians, patient selection for surgery and consideration of neoadjuvant therapy may be increasingly important.

Volume

25

Issue

10

First Page

2582

Last Page

2592

ISSN

1873-4626

Disciplines

Medicine and Health Sciences

PubMedID

33634421

Department(s)

Department of Surgery, Lehigh Valley Topper Cancer Institute

Document Type

Article

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