The Role of the Microbiome in Gastroentero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs).
Publication/Presentation Date
4-30-2022
Abstract
Gut microbiome balance plays a key role in human health and maintains gut barrier integrity. Dysbiosis, referring to impaired gut microbiome, is linked to a variety of diseases, including cancers, through modulation of the inflammatory process. Most studies concentrated on adenocarcinoma of different sites with very limited information on gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). In this study, we have analyzed the gut microbiome (both fungal and bacterial communities) in patients with metastatic GEP-NENs. Fecal samples were collected and compared with matched healthy control samples using logistic regression distances utilizing R package MatchIt (version 4.2.0, Daniel E. Ho, Stanford, CA, USA). We examined differences in microbiome profiles between GEP-NENs and control samples using small subunit (SSU) rRNA (16S), ITS1, ITS4 genomic regions for their ability to accurately characterize bacterial and fungal communities. We correlated the results with different behavioral and dietary habits, and tumor features including differentiation, grade, primary site, and therapeutic response. All tests are two-sided and
Volume
44
Issue
5
First Page
2015
Last Page
2028
ISSN
1467-3045
Published In/Presented At
Mohamed, A., Asa, S. L., McCormick, T., Al-Shakhshir, H., Dasari, A., Mauricio, R., Salem, I., Ocuin, L. M., Bajor, D., Lee, R. T., Selfridge, J. E., Kardan, A., Lee, Z., Avril, N., Kopp, S., Winter, J. M., Hardacre, J. M., Ammori, J. B., & Ghannoum, M. A. (2022). The Role of the Microbiome in Gastroentero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs). Current issues in molecular biology, 44(5), 2015–2028. https://doi.org/10.3390/cimb44050136
Disciplines
Medicine and Health Sciences
PubMedID
35678665
Department(s)
Department of Surgery, Lehigh Valley Topper Cancer Institute
Document Type
Article
