Intracerebral Transplantation of Autologous Mesenchymal Stem Cells Improves Functional Recovery in a Rat Model of Chronic Ischemic Stroke.
Publication/Presentation Date
4-1-2025
Abstract
While treatments exist for the acute phase of stroke, there are limited options for patients with chronic infarcts and long-term disability. Allogenic mesenchymal stem cells (alloMSCs) show promise for the treatment of stroke soon after ischemic injury. There is, however, no information on the use of autologous MSCs (autoMSCs), delivered intracerebrally in rats with a chronic infarct. In this study, rats underwent middle cerebral artery occlusion (MCAO) to induce stroke followed by bone marrow aspiration and MSC expansion in a closed bioreactor. Four weeks later, brain MRI was obtained and autoMSCs (1 × 10
Volume
16
Issue
2
First Page
248
Last Page
261
ISSN
1868-601X
Published In/Presented At
Myers, M. I., Hines, K. J., Gray, A., Spagnuolo, G., Rosenwasser, R., & Iacovitti, L. (2025). Intracerebral Transplantation of Autologous Mesenchymal Stem Cells Improves Functional Recovery in a Rat Model of Chronic Ischemic Stroke. Translational stroke research, 16(2), 248–261. https://doi.org/10.1007/s12975-023-01208-7
Disciplines
Medicine and Health Sciences
PubMedID
37917400
Department(s)
Department of Surgery
Document Type
Article
