Impact of recipient age on whole organ pancreas transplantation.
Publication/Presentation Date
1-1-2013
Abstract
AIM: The goal of this study was to assess the impact of recipient age on post-transplant outcome.
METHODS: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates.
RESULTS: Patients (n = 405) were divided by decade: < 30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥ 60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the < 30 yr group (74%), while all other groups were similar around 80% (p = NS).
CONCLUSION: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.
Volume
27
Issue
1
First Page
49
Last Page
55
ISSN
1399-0012
Published In/Presented At
Shah, A. P., Mangus, R. S., Powelson, J. A., Samy, K. P., Taber, T. E., Goble, M. L., & Fridell, J. A. (2013). Impact of recipient age on whole organ pancreas transplantation. Clinical transplantation, 27(1), E49–E55. https://doi.org/10.1111/ctr.12047
Disciplines
Medicine and Health Sciences
PubMedID
23228216
Department(s)
Department of Surgery
Document Type
Article
