AGO2 Mediates
Publication/Presentation Date
4-1-2020
Abstract
Deregulated RNA-binding proteins (RBP), such as Argonaute 2 (AGO2), mediate tumor-promoting transcriptomic changes during carcinogenesis, including hepatocellular carcinoma (HCC). While AGO2 is well characterized as a member of the RNA-induced silencing complex (RISC), which represses gene expression through miRNAs, its role as a bona fide RBP remains unclear. In this study, we investigated AGO2's role as an RBP that regulates the
Volume
18
Issue
4
First Page
612
Last Page
622
ISSN
1557-3125
Published In/Presented At
Zhang, K., Pomyen, Y., Barry, A. E., Martin, S. P., Khatib, S., Knight, L., Forgues, M., Dominguez, D. A., Parhar, R., Shah, A. P., Bodzin, A. S., Wang, X. W., & Dang, H. (2020). AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma. Molecular cancer research : MCR, 18(4), 612–622. https://doi.org/10.1158/1541-7786.MCR-19-0805
Disciplines
Medicine and Health Sciences
PubMedID
31941754
Department(s)
Department of Surgery
Document Type
Article